Acute Toxicity Studies and Sleep-wake Eeg Analysis of Stachytarpheta Cayennensis (verbenaceae) in Rats and Mice

This study was carried out in order to establish the scient medicinal use of Stachytarpheta cayennensis (Verbanace toxicity and barbituric-hypnotic test of the total aqueous and butanol (SCBT), ethylacetate (SCEA) fractions of were studied in male rats and mice. The effect of system sleep architecture in rats was also evaluated in Sp chronically implanted with electrodes for electr electromyogram (EMG) recording. The acute toxicity tes doses of SCCR (up to 2000 mg/kg) per oral in rats an mg/kg and 95 mg/kg) systemically in rats and mi significantly (p<0.01) potentiated phenobarbital-induce latency and increasing sleeping time in a dose-depende administration of single doses (250 and 500 mg/kg) 30 m period of TASC significantly (p<0.05) increased total rapid eye movement (NREM) sleep during the 6-h reco REM sleep was biphasic with the higher dose admini Stachytarpheta cayennensis showed profound effects on the potential sedative effects.